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KMID : 0357919730070010063
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Korean Journal of Pathology
1973 Volume.7 No. 1 p.63 ~ p.68
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The Effect of Cortisone on Transformation of Sensitized Allogenic Rabbit Thoracic Lymphocytes in Diffusion Chamber
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Abstract
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The method of diffusion chamber cultivation was found to be appropriate to observe
the potentialities of lymphocytes (Schelton & Rice, 1959 ; Schooley & Berman, 1960 ;
Holub, 1958, 1960, 1962), The possibility of separating practically pure suspensions of
small thoracic duct lymphocytes enabled us to observe directly the nature of these cells.
Holub confirmed that the small lymphocytes from rabbit thoracic duct lymph cells were
found capable of being changed to antibody-producing plasmacytoid cells morphologically
and functionally when homotransplanted either with or without protein antigen. Bai &
Kim (1972) observed the effect of cortisone on the transformation of autologous small
lymphocyte of rabbit in diffusion chamber inserted intraperitoneally and confirmed that
there was transformation of small lymphocyte into blastic form. Park and Kim (1972)
reported allogeneic thoracic lymphocytes in diffusion chamber in cortisone treated rabbits
were transformed to blastic form.
We made an attempt to observe the effect of cortisone on transformation of egg-
albumin sensitized allogeneic rabbit thoracic lymphocyte in diffusion chamber following
resensitization.
The results were as follows :
Sensitized allogeneic thoracic lymphocytes in diffusion chamber were decreased in total
number following challenge either by means of intraperitoneal injection or local
administiation of the same antigen respectively, and/or following those treatment plus
injection of cortisone. The transformations into blastic forms were prominent only of the
lymphocytes in the challenged group by means of intraperitoneal injection of the same
antigen.
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